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Less common B12 shot side effects include : Chest tightness Skin rash or hives Dizziness Difficulty breathing A blue tint to the skin Call your doc ASAP if you notice any of these negative effects

Subcutaneous administration of vitamin B12 is sometimes employed, especially in patients with congenital cobalamin metabolism disorders who require high doses to maintain normal metabolic pathways

Serious Reactions That Require Medical Attention Whilst most reactions to B12 injections are mild, certain symptoms indicate potentially serious complications requiring prompt medical assessment