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Standards and Regulatory Compliance Confirm that all machinery strictly complies with international and local standards, including ISO 9001:2015 for quality management, CE marking for European market access, FDA regulations where applicable, the EU Tobacco Products Directive (TPD), and OSHA/ILO safety guidelines

Smokers may compensate by inhaling more deeply or smoking more frequently

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We used these characteristics as a proxy for socioeconomic classification, the primary criteria specified in the TPackSS protocol