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A multinomial logistic regression is done to determine the association

Differences in study population selections, definitions of early-onset smokers, and considerations for confounding variables may have also contributed to the inconsistent results from studies based on United States data 14,15,22,23,24

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Besides defense responses, significant enrichment was observed in metabolic processes such as sesquiterpene biosynthetic process, terpene synthase activity, and carbonoxygen lyase activity, as well as in photosynthesis-related processes including negative regulation of photosynthesis and photoinhibition. Taken together, these analyses indicate that flue-cured and cigar tobacco types employ distinct metabolic and defense strategies during late-stage development, which may underlie their phenotypic and biochemical divergence