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Fifty-three (4.3%) patients in the cytisine group and 46 (3.7%) in the placebo group reported serious adverse events (SAEs) (94 events in the cytisine group and 90 events in the placebo group), which included 91 deaths (49 in the cytisine group and 42 in the placebo group)

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For example, citizens increasing health awareness surely plays a role, as do annually rising tobacco taxes every year, said Yusuke Suzuki, general manager of TIOJs heated tobacco product planning division

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Moreover, there is a need to consider adverse consequences of marketing lower risk products