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The Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP) ALL-BFM-2000 (NCT00430118) trial randomly assigned 3,720 patients to receive either dexamethasone (10 mg/m2/d) or prednisone (60 mg/m2/d) during multiagent remission induction (including an anthracycline for all patients) after a 7-day prednisone prophase.[9] Dexamethasone was associated with higher incidence of life-threatening events (primarily infections), resulting in a significantly higher induction death rate (2.5% for dexamethasone vs

Jacob F, Salinas RD, Zhang DY, Nguyen PT, Schnoll JG, Wong SZH, et al

Histological findings further supported these outcomes, revealing an increase in body weight, which had been decreased by the induction of colitis

Fall protection at tanks before they were filled with water was a major focus for the duration of the project

Zhang L, Liu Y, Lu Y, Wang G

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