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Metamorphosis & the Tobacco Hornworm (Manduca sexta) Hornworms on the Tomatoes Home & Garden Information Center How to tell the difference between Tobacco Hornworm and Tomato Hornworm? The tobacco hornworm (Manduca sexta) is one of the most well known caterpillars in North America, for better or for worse. Perhaps a hate it or love it species, but we certainly love them at Tough to be a hornworm: Tomato and tobacco hornworms, Manduca quinquemaculata< i> and M. sexta< i> Bug of the Week How to Identify Tomato and Tobacco Hornworms Homestead Honey