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When we extended this analysis to creatinine concentrations below and above (5 M1 mM) the physiological plasma concentration of creatinine (75 M) (28) using 13 C-creatinine, we found a positive linear relationship between 13 C-CR and 13 C-creatinine levels in CR hi cell lines (Figure 3, G and H), confirming the direct conversion of creatinine into CR

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