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Older adults, especially in isolation and those with cognitive decline/dementia, may become more anxious, angry, stressed, agitated and withdrawn during the outbreak or while in quarantine

And so we had to think through a completely different approach to it, a completely different strategy

Low-dose naltrexone (LDN) has emerged as one of the most promising agents in this area, working through glial cell modulation to reduce neuroinflammation and through toll-like receptor pathways to quiet abnormal immune activation

The ratio of GSH to GSSG is a key indicator of cellular oxidative stress, with a healthy cell maintaining a ratio greater than 100:1 [2][5]

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10.1016/j.freeradbiomed.2018.09.043 66 HouW.XieY.SongX.SunX.LotzeM