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Importantly, BPC-157 shows no direct angiogenic effect on endothelial cell cultures, suggesting its pro-angiogenic activity requires the context of injury and healing responses present in vivoa safety feature that may limit unwanted neovascularization in healthy tissues

The medication BPC 157 was applied either once, at 1 min after defect creation as an abdominal bath (1 mL/rat) to assess the initial post-injury course, blood vessel presentation, or to assess the subsequent course leading to adhesion formation intraperitoneally once daily, with the first application at 30 min after surgery and the last application 24 h before the assessment

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Recurrence or metastasis of HCC: predictors, early detection and experimental antiangiogenic therapy