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Inhibition of vitamin K epoxidase decreases the synthesis of these clotting factors, but the complex has a long half-life (about 14 hours), and it is this half-life that determines how long it takes for the concentration of clotting factors to reach a new steady state and for a drug effect to reflect the average warfarin plasma concentration

Flushing is essentially the blood vessels near the skin overgrowing and dilating, allowing more of the fresh blood in these vessels to be seen through the skin

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