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Whether partial TCA cycle reverse activity due to the large accumulation of fumarate, leading to SDH reversal and fumarate reduction to succinate, as it has been observed in ischaemia [36], or cells treated with mitochondrial inhibitors [37], occurs in Fh -1 deficient cells has not been reported

Additionally, signaling pathways such as PI3K/Akt/mTOR and metabolites like succinate can also regulate the expression and stability of HIF-1 (71, 72)

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Individuals who are homozygous for the null-GSTM1 or null-GSTT1 genotypes lack the respective enzyme functions (Seidegaard et al, 1986

(195) constructed HS-CAR-T cells incorporating a 7HE heat shock promoter, which restricts CAR expression and activation to heated areas/time periods, thereby reducing off-target toxicity and potentially preventing T cell exhaustion