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Nevertheless, both intravenous and vapor nicotine self-administration paradigms are valuable tools to investigate various aspects of nicotine dependence, and established protocols demonstrate blood levels of nicotines metabolites, cotinine, 5-hydroxycotinine and cotinine N-oxide, similar to that found in human smokers (60, 62, 65, 7274)

doi: 10.1042/CS20160268 11

Cigars often have higher nicotine content

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The original popcorn lung cases involved prolonged inhalation of extremely high levels of diacetyl without adequate protective equipment