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Mansour et al., 2016)

Recently, N1097 of mTRPM7 was also indicated to form the intracellular Mg 2+ regulatory site, because the N1097Q mutation abrogated the inhibition of TRPM7 channel by physiological intracellular Mg 2+ concentration (Schmidt et al., 2022)

and other sources of bias

Both patients were previously on hCG treatment as an adjunct to their TRT, however their hCG treatment was ceased 7 days prior to study commencement as a wash-out period, and baseline serum hCG levels were confirmed to be 1mIU/mL for up to 3 days (72 hours) following a single injection

Cantin et al., 2007

Suggested Titration Protocol Suggested peptide titration protocol: Start with 100 mcg of each peptide daily by subcutaneous injection , then increase the dose by around 50 mcg every 12 weeks as tolerated