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Recent studies also reveal sex differences in mitochondrial responses: post-LPS exposure, male mice show upregulation of mitochondrial complexes I, III, and V proteins, while females exhibit downregulation of complexes III and IV

Defense-specific pathways, particularly the response to biotic stimulus (GO:0009607), were significantly upregulated, emphasizing their role in pathogen resistance (Fig

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10.1084/jem.20070956 159 VermotA.Petit-HrtleinI.SmithS