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A recent study suggested that there may be multiple reasons for remyelination failure in MS patients, according to lesion stage: in a subset of active lesions, a lack of myelin sheath formation was observed despite the presence of mature OLGs, whereas in inactive lesions, OLG loss and a hostile microenvironment were identified as the major causes of remyelination failure (He et al., 2020)

ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator

Of the 216 enrolled patients, 102 (47.2%) were not included in the primary analysis because of incomplete questionnaires or loss to follow-up

Journal of Clinical Orthopaedics and Trauma , 15, 145151

Rodrguez-Manzaneque MT, Tamarit J, Bell G, Ros J, Herrero E