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Studies have shown that TCA cycle activity decreases significantly with age, which directly leads to an imbalance in the NAD+/NADH redox state and a decrease in the intracellular NAD+ level [81]

Something seems to be going on at cell level

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doi: 10.1038/s41577-020-0311-8 86 ThakurK

Plant-derived bioactive peptides and protein hydrolysates for managing MAFLD: a systematic review of in vivo effects

Abbreviations ARI: Aripiprazole BDNF: Brain-derived neurotrophic factor BSO: L-buthionine-(S, R)-sulfoximine CAT: Catalase CpG: Cytosine-guanine Cys: Cysteine CBS: Cystathione -synthase DA: Dopamine ESC: Escitalopram GABA: Gamma-aminobutyric acid GBR: 12909 1-[2-[Bis-4(fluorophenyl)methoxy]ethyl]-4-3-(3-phenylpropyl) GCL: Glutamate-cysteine ligase GCLC: Glutamate-cysteine ligase catalytic subunit GCLM: Glutamate-cysteine-ligase modifier subunit GPx: Glutathione peroxidase GR: Glutathione reductase GSH: Glutathione GSSG: Glutathione disulfide Hcy: Homocysteine hpGPx: Human plasma glutathione peroxidase 5-HT: Serotonin MAO: Monoamine oxidase Met: Methionine MIR: Mirtazapine MST: Mercaptopyruvate sulfurtransferase NAC: N-acetylcysteine NMDA: N-acetyl- D -aspartate acid ODS: Osteogenic Disorder Shionogi ROS: Reactive oxygen species SAM: S-adenosyl-methionine SOD: Superoxide dismutase References Lewis DA, Lieberman JA