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10.1007/s00062-011-0063-8 252 UryuK.ChenX.-H.MartinezD.BrowneK

To use aloe vera gel for melanin reduction, extract fresh aloe vera gel from an aloe leaf and apply it directly to the face

At high concentrations, this interaction causes direct membrane destabilization, whereas lower concentrations promote endocytic entry (Steinstraesser et al., 2011