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Accordingly, production of the endogenous antioxidant glutathione (GSH) by glial cells within the brain [8], particularly astrocytes [8,9,10], is a critical function, as most antioxidants are unable to cross the blood brain barrier

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Several of these genes are polymorphic, resulting in phenotipic variants of GSTs

As the major source of intracellular ROS, mitochondria are constantly challenged and damaged by ROS accumulation

Theranostics 8 , 14681480 (2018)

Conclusions: Overall, our WBD protocol provides a one-shot comprehensive evaluation of human hematopoietic system in a wide range of pre-clinical and clinical applications going from the characterization of hematopoietic disorders to the monitoring of hematopoietic reconstitution and HSPC maintenance in patients after transplant or gene therapy