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NMR-based metabolomic analysis Dry extracts were thawed at room temperature, mixed with 180 L D 2 O and 20 L phosphate buffer (1.5 M KH 2 PO 4 in D 2 O containing 2 mM NaN 3 and 0.1% trimethylsilyl propionic acid [TSP], pH 7.4), and transferred to 3-mm NMR tubes

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Li et al.'s quantitative analysis showed reduced mitochondrial area in the SAH group, while the SAH + Fer-1 group exhibited improved mitochondrial morphology (Li et al., 2021c)

JP Andrade, Dr

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For example, in hepatocellular carcinoma (HCC), ferroptosis serves as a tumor-suppressive mechanism in early stages but becomes dysregulated in advanced disease, suggesting that dynamic modulation may be necessary during different phases of neurodegeneration