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Insulin Independent Pathways for Glucose Disposal GLP-1: Increase in GLUT4 expression by activating AMPK LeuSynergy: Increase in GLUT4 expression through SIRT1 deacetylation of PGC-1a Improved Fat Oxidation GLP-1: Direct effects on hepatocytes by activating genes involved in beta-oxidation of fatty acids LeuSynergy: Activation of PGC-1a and PPAR resulting in an increase in fatty acid oxidation and oxidative phosphorylation Oxidative Stress and Pancreatic Beta Cell Protection GLP-1: Reduced oxidative stress in pancreatic islets

Commonly used NSAIDs include ibuprofen, motrin, Aleve, naproxen, naprosyn, Celebrex, celecoxib, Advil, Excedrin, Aspirin, Toradol, ketorolac, and diclofenac

Naguib G

Proteins like these can sense nutrient availability and thus can bridge the NAFLD genetics with the environment

Results vary from person to person based on their baseline levels and lifestyle

Ajzenman (Hospital Andr Mignot Pediatrie, France)