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Biochemistry 52 , 81878197 (2013)

Botticelli et al

Plant cells challenged with an increase in H 2 O 2 use their antioxidant machinery to keep it under control [14]

Since GSSG is then enzymatically reduced by glutathione reductase, GSH is the dominant form in organisms

It was found that STZ induced a decrease in autophagic activity in podocyte cells after diabetes, which ultimately led to the development of DKD (167), and the abnormalities of sphingolipids and CHOL exhibited by lipid metabolism disorder in patients with DKD may be responsible for the inhibition of autophagy in DKD podocyte cells

348 In RA, inflammatory activation with excessive ROS further damage the synovium, vessels, and joints