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7.4 Gut microbiota dysbiosis and metabolic-endocrine crosstalk The gradual buildup of abnormal protein aggregates in the central nervous system (CNS) is a key characteristic of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) (129)

Current drugs to treat Alzheimers disease Available FDA approved drugs to treat AD fall into two major classes (Table 1): 1) Namenda (memantine HCl) acts as an N-methyl-D- aspartate (NMDA) receptor antagonist designed to limit glutamate excitotoxicity and resulting neuronal damage [15-17]

Safety & Cautionary Notes Combining therapies sounds appealingbut its not without nuance

Heart palpitations and caffeine sensitivity would mean the person benefits from eating caffeine-free stuff

Damaged mitochondria are not removed in time and accumulate to form waste mitochondria, which release more ROS, accelerating muscle atrophy (44)