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MOTS-c has been studied in preclinical research models for its interactions with AMPK (AMP-activated protein kinase) signaling pathways, glucose metabolism regulation, and insulin sensitivity mechanisms, making it a research tool of particular interest to investigators studying mitochondrial biology, metabolic signaling, and cellular energetics

However, currently, there is a lack of systematic review of these studies, although a few reviews tend to report the efficacy and safety of Korean RG in male diseases by meta-analysis [14]

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Though rare, serious side effects require prompt medical attention as they can affect organs such as the kidneys, pancreas, gallbladder, and eyes

Among these, SpoVM and CmpA are small proteins that coordinate cortex and coat formation, SpoVM attaches the coat to the spore surface, while CmpA serves as a checkpoint, delaying cortex assembly until coat synthesis commences (Ebmeier et al

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