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As we have previously discussed, the MSR/MLR protects against an ACO earning shared savings or being liable for shared losses when the change in expenditures represents normal, or random, variation ( rather than an actual change in performance (see, for example, 83 FR 67923 through 67926)

DUPIXENT is a prescription medicine used: to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies

Monitoring: Because long-term data are sparse, ongoing follow-up is wise

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For topical research applications, our team often sees concentrations ranging from 0.05% to 0.5% (w/v) AHK-Cu in a suitable carrier solution as a common starting point