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In addition, other ferroptosis inhibitors have been identified, including deuterated polyunsaturated fatty acids (D-PUFAs), inhibitors of acyl-CoA synthetase long chain family member 4 (ACSL4), glutaminolysis inhibitors, LOX inhibitors, cycloheximide, beta-mercaptoethanol, dopamine, selenium, and vildagliptin [2]

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3a), and it remained significantly lower than CIP at 48 h and 72 h following treatment ( p = 0.0002, 0.0269, respectively) (Fig

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KipperBHTrevizanJTCarreiraJTCarvalhoIRMingotiGZBelettiMEet al

Using distinct HIF-1 antibodies for staining macrophages, dual-positive immunofluorescence for HIF-1 + and CD206 + macrophages was detected in proximity to capillaries (186), indicating that vascular neogenesis in jDM patients is regulated by the VEGF/HIF pathway, inducing HIF-1 and promoting CD206 expression in macrophages, which may lead to hypoxic damage to capillaries in DM patients