Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP peg3 AN2 reduces the levels of

AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons

Product Name DOTA-tris(t-Bu)ester-PEG3 Synonyms CAS Number n/a Related CAS Molecular Formula C34H65N5O10 Molecular Weight 703

632 Purity (HPLC) >= 95% Solubility DMSO

404 SMILES OCCOCCOCC#CC1=CC=C2C(CN(C3CCC(=O)NC3=O)C2=O)=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Mal-Propionyl-Dap(m-PEG4)-Val-Cit-OH Synonyms CAS Number Related CAS Molecular Formula C31H51N7O13 Molecular Weight 729

Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP peg3 AN2 reduces the levels ofSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP