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E-cigarette aerosol can contain: highly addictive nicotine that can harm brain development ultrafine toxic particles that can interfere with the growth and work of the lungs and increase the risk of heart disease, lung cancer, and asthma attacks harmful heavy metals such as lead, tin, and nickel volatile organic compounds that can cause long-term health effects including cancer

As of December 31, 2022, seven states (California, Maryland, Massachusetts, New Jersey, New York, Rhode Island, and Utah) and 378 jurisdictions, including counties, cities, towns, and villages, have some type of restriction on flavored e-cigarette sales in place

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Smoking is directly responsible for approximately 80 percent of deaths caused by chronic obstructive pulmonary disease (COPD), including emphysema and chronic bronchitis

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Device characteristics and use patterns further modulate the chemical composition of e-cigarette aerosol