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The drug binds to PXR, forming an activated complex, and subsequently combines with the retinoid X receptor (RXR) to form a heterodimer that targets a DNA response element, enhancing CYP3A4 gene transcription

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Some are contained directly in the tobacco leaf, others are produced when the cigarette burns and some have been added by the cigarette manufacturers

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and the weight per thousand cigarettes is established using the following formula: (actual number of long cigarettes multiplied by mass excluding filters) divided by number of separate dutiable per M long cigarettes equals = mass per M for duty purposes Return of Canadian Manufactured Tobacco Products 17