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Key Points L-Arginine is the substrate of endothelial nitric oxide synthase and the main precursor of nitric oxide in the vascular endothelium Evidence indicates that intra-arterial or intravenous infusion of L-arginine rapidly improves nitric oxide bioavailability in the coronary arteries in both animal models and humans Oral treatment with L-arginine seems to improve endothelial function in high-risk patients, but this effect is not observed in healthy individuals, or in patients with coronary atherosclerosis or myocardial infarction who are receiving optimum medical treatment Although L-arginine is not associated with any serious adverse effects, there is still no conclusive evidence for its use for primary or secondary prevention of adverse cardiovascular events This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

Cangut, B, Sakowitz, S, Rajah, T, Papageorge, MV, Boyd, R, Lin, N, Stanley, M, Blackmon, SH, Molena, D, Watkins, AA, Worrell, SG, Antonoff, MB

10.4149/neo_2022_221007N992 121 MinY

Commun 14, 543549

Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2

Notably, ATO-VAC showed substantial therapeutic potential, as the administration of this vaccine to TC-1 cell-bearing mice significantly reduced tumor growth