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S.KyadaR.YousefiF.PleshkoN.et al (2018)

Interestingly, a positive feedback loop between miR526b/655 and oxidative stress was identified in breast cancer, and the loop promotes tumor growth and metastasis [67]

While direct evidence in humans is limited (for obvious ethical reasons), the mechanism of action is concerning enough to make this one of the most serious GHK-Cu contraindications