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JAMA 296:4755 Jorenby DE, Hays JT, Rigotti NA, Azoulay S, Watsky EJ, Williams KE et al (2006) Efficacy of varenicline, an a4b2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial

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Principal component analysis of TCR regions showed that, in contrast to the clonal aggregation of T cells in control mice, smoke exposure resulted in an increased in clonal diversity among airway T cells at both 2 and 6 months (Fig