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This transformation leads to an increase in glycolysis-related genes and antioxidant and stress processes associated genes downregulating [383]

This article examines the side effect profile of B12 therapy in older adults, covering common reactions such as injection site discomfort and gastrointestinal symptoms, rare serious adverse events requiring urgent medical attention, important drug interactions with medications like proton pump inhibitors and metformin, and evidence-based dosing guidance aligned with NICE and BNF recommendations for safe, effective B12 replacement in this vulnerable population

Free Radic Biol Med 87:226236

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Another contributing factor to excess melanin is poor nutrition

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