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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Investigations In many cases the diagnosis is clinical, however, if a biopsy is needed the characteristic feature is a band of hyalinization of the dermal collagen below the epidermis Management Extra-genital lichen sclerosus Topical treatments are generally much less effective than when used to treat genital LS

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Since its inception, the agreement has reshaped the tobacco industry via strict advertising restrictions while providing states with ongoing compensation tied to the public health costs of smoking

Similarly, harm reduction recognizes that patients exist along a continuum of readiness for change and that meaningful improvements in health can occur even when abstinence is not immediately achievable

But the loss to the individual and his (or her) family is no less tragic