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Hydroxytyrosol and oleuropein are the main components of the polyphenolic fraction of Olea europaea , and their antioxidant potential has long been recognized

Besides GSH conjugation, several activities were found to be associated with GSTs in both plant and animal system such as high steroid isomerase activity, leukotriene biosynthesis, formation of oxylipins (precursor of jasmonic acid), double bond cis/trans isomerization, michael addition, mesotrione degradation, dehydroascorbate reduction, non-catalytic ligand binding and transport, signal transduction [5] and protection against ozone damages [6]

doi: 10.1093/braincomms/fcad353 154 BudimirovicDBDominickKCGabisLVAdamsMAderaMHuangLet al

Pathogen infection induces oxidative stress in cells, increasing ROS levels, which can activate antioxidant pathways, such as increased GPX activity

they produce interferon-gamma, aggravating IRI [36]

Immunogenicity assessment for GX-G3-administered rats and monkeys To evaluate the immunogenicity of GX-G3 in a 4-week repeated-dose toxicity study, rats and monkeys were treated once a week via subcutaneous injection of 0 (vehicle control) 1, 3, or 10 mg/kg GX-G3