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After fermentation, the leaves are aged in a cool environment (typically 65F) for anywhere from six weeks to six years to develop complexity

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Am J Physiol Heart Circ Physiol 317(2):H445Hh59 Hom S, Chen L, Wang T, Ghebrehiwet B, Yin W, Rubenstein DA (2016) Platelet activation, adhesion, inflammation, and aggregation potential are altered in the presence of electronic cigarette extracts of variable nicotine concentrations