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This observation has significant physiological implications, suggesting that ABCC1 may regulate the labile iron pool, mitigate elevated intracellular iron levels, and contribute to defense against iron toxicity

The oral squamous cell carcinoma (OSCC) and epidermoid oral carcinoma are the most frequent malignant cancers, representing 9095% of cases

Since chemotherapy-associated inflammation is regarded as a key mechanism of neuroinflammation involved in OIPN [84], the complex interaction between neurons, immune system, and cancer cells must be considered

Although long considered a universally essential element for life, these rare exceptions suggest that Fe is a class (ii) element

This is important for protecting cells from oxidative stress and keeping an immune system that works well

Greater standardisation and transparent reporting will be essential to improve reproducibility and translational value