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Here are the main ways in which smoking affects kidney function: Nicotine and carbon monoxide, two of the many harmful substances found in cigarette smoke, narrow blood vessels and lower oxygen levels in the bloodstream

To enhance the translational relevance of animal studies, future research should emphasize the use of humanized gnotobiotic models, which are colonized with microbiota derived from well-characterized cohorts of smokers and nonsmokers

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When DNA becomes damaged, p53 helps determine whether the DNA will be repaired or the cell will self-destruct and undergo apoptosis