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Several studies have highlighted that the tumor microenvironment is characterized by an immunosuppressive profile, often associated with high levels of oxidative stress and inflammation [40, 42, 68]

All samples were derived from peripheral blood

Nausea, vomiting, and headaches could occur as rare side effects, especially with high doses or if youre sensitive to the treatment

Previous studies have shown that high levels of ROS in rats with fibrosarcoma can limit the adhesion of NK cells to similarly charged tumour cells by promoting the accumulation of anionic charges on their surface

10.3382/ps.2009-00531 32

As IGF-1 is known to stimulate the proliferation of chondrocytes in vitro (2124), the dramatic reduction of IGF-1 levels in these animals is consistent with decreased bone growth