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Antiplatelet drugs The thienopyridine P2Y12 inhibitors clopidogrel and prasugrel are converted to their active metabolites by CYP isoenzymes, including CYP1A2, CYP2B6, CYP2C19, CYP3A4/5 and CYP2C9, thus enzyme induction by smoking could theoretically increase the antiplatelet activity of these agents

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Smoking patterns were grouped based on adult tobacco use classifications of the Centers for Disease Control and Prevention (CDC)