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Recently identified melanoma stem cell markers include JARID1B (jumonji, AT-rich interactive domain 1B), ABCB5 (ATP-binding cassette subfamily B (MDR/TAP) member 5), ABCG2 (ATP-binding cassette subfamily G member 2), and MDR1 (multi-drug resistance 1) [27]

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NAD+ (nicotinamide adenine dinucleotide), an essential coenzyme present in all living cells, activates sirtuins and supports DNA repair, mitochondrial function, and metabolic regulation -- touching multiple hallmarks simultaneously

Some small drugs - such as L-DOPA used to treat Parkinsons - can be ferried in on natural nutrient transport systems, but this approach has complications in finding the right dosing regime, as patients transporters have differing efficiencies