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However, their clinical application faced challenges related to variable bioavailability, individual pharmacokinetics, optimal dosing, and limited clinical evidence

Indeed, CFTR upregulation was shown to lead to increased apoptosis in endometrial epithelial cells, as well as to abnormal fluid accumulation within the uterine lumen, hence disrupting the supportive environment needed for successful embryo implantation [7, 33,34,35]

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Mohan R , Mageras G, Baldwin B, Brewster L, Kutcher G, Leibel S, Burman C, Ling C, Fuks Z