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and also to act as a negative feedback loop to suppress chronic activation of the ATF4/CHOP-mediated, pro-steatotic and pro-apoptotic pathway

While the greater amount of cellular reduced GSH is found in the cytosol and mitochondria, the endoplasmic reticulum becomes a reservoir of small concentrations of the oxidized form of GSH (GSSG)

In PTSD mice models, trauma exposure increased tyrosine hydroxylase expression (the rate-limiting enzyme in catecholamine biosynthesis), elevating stress hormones epinephrine and norepinephrine in serum and colon, which upregulated claudin-2 expression, confirming gut barrier dysfunction (Yadav et al., 2023)

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Nature

[DOI] [PubMed] [Google Scholar] 36.Rinella M.E., Sookoian S