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Manic episodes are defined by at least 1 week of persistently elevated, expansive, or irritable mood accompanied by increased activity or energy, whereas hypomanic episodes present similar features without marked functional impairment or hospitalization

GIT1 binding to mTOR was found to be regulated by AKT and to be essential for mTOR-mediated astrocyte survival

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However, in response to oxidative stress, GPX7 can promote stress signal transduction and release through interaction with corresponding targeted proteins