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The reduction of illness, disability, and death related to tobacco use and secondhand smoke exposure is a guiding principle of the activities of TFL

4.1 Strengths and limitations Study strengths include the large sample size, and comparison of results between two settings (one high-income, one middle-income) that have different norms, cultural traits, regulatory contexts, network structures, and health behavior patterns

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our research shows strong evidence of an association between an increase in safer nicotine products use and a corresponding decrease in smoking Japan and heated tobacco products Heated tobacco products first became available in Japan in 2014, and the growth in their use over the following ten years has been remarkable