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Since the simple act of feeding induces ER stress independent of dietary fat content, at least in the liver (Gomez and Rutkowski, 2016), it is possible that the consequences of obesity on ER function depend on whether or not the stimulus is experienced as accelerated feeding and fasting cycles, as in ob/ob mice, or as more calorically potent episodes of feeding with relatively normal frequency

An advanced comprehension of the basic biology of CHAC enzymes, derived from rigorous biochemical and genetic studies, is therefore a prerequisite for their rational therapeutic exploitation

2025 Jul 16:241:117178

doi: 10.1016/j.freeradbiomed.2023.08.020

While many patients feel better with B12, its not required for everyone