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Therefore, by activating this NCOA4-mediated ferritinophagy pathway, Erastin promotes the release of free iron, which in turn amplifies ROS production and lipid peroxidation, resulting in an autophagy-dependent mode of ferroptosis

Key Benefit NAC primarily works as a building block for glutathione production

10.1007/s00018-016-2314-y 141 MerkleF

Identification of two benzopyrroloxazines acting as selective Gper antagonists in breast cancer cells and cancer-associated fibroblasts