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In terms, the spacer was substituted by a nitro group in order to increase the rate of self-immolation

199,200 Cyclin D1 (CCND1), cyclin E1 (CCNE1), cyclin-dependent kinase 2 (CDK2), and cyclin-dependent kinase 4 (CDK4) are all cell cycle regulation-related proteins/genes, while CCND1 and CCNE1 are key molecules for G1 phase progression

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Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes

doi: 10.1186/1756-3305-4-180 [DOI] [PMC free article] [PubMed] [Google Scholar] 118