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Oxidative damage to mtDNA leads to a positive feedback loop in ROS production as the ETC enzymes encoded by mtDNA are damaged, impairing the ETC and increasing electron leakage (Rice et al., 2011

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Yes, vaping too frequently or using overly concentrated nicotine salt profiles can cause mild dehydration or sudden constriction of blood vessels in your brain, both of which are prominent triggers for short-term tension headaches

Doug Jorenby, a UW-CTRI researcher on the project