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doi: 10.1016/j.neuroimage.2005.02.042

Elucidating the gut microbiome of ulcerative colitis: bifidobacteria as novel microbial biomarkers

Assuming an increased ROS-level and a decreased level of glutathione, especially the reduced form, as an important antioxidant in Wobbler motor neurons, it can be concluded that NAC, as a precursor of glutathione, can replenish the GSH content and thus reduce oxidative stress in Wobbler motor neurons resulting in less oxidative DNA damage

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c,dJIMMY GUTMAN, MD aWashington Dermatology Center, North Bethesda, Maryland

Previous work has shown that the clock regulates NAD + biosynthesis and deacetylation pathways that, in turn, regulate mitochondrial enzyme activity 4,35