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Bromelain has been extensively studied for its implication in cell death, indeed it can intervene in the expression of Bcl-2, a type of protein with an anti-apoptotic effect but can also positively regulates the expression of apoptotic genes, such as Bax, Apaf-1, and caspases-9 and -3 ( In vitro studies have shown that bromelain can induce apoptosis

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10.1016/bs.acc.2023.05.003 209 ZhangY.NeogiT.ChenC.ChaissonC.HunterD

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Flavonoids have other actions that block fibroids including prebiotic effects, optimizing life-and-death cell cycle regulation, and improving overall redox and immune balance